Back to Glomerular Disease
The H & E Process
Hematoxylin and Eosin (H&E) is the cornerstone of renal pathology. Hematoxylin binds to acidic structures (DNA/RNA) staining them deep blue-purple, while Eosin binds to basic proteins (cytoplasm/extracellular matrix) staining them shades of pink.
Clinical Correlation
Findings of diffuse hypercellularity and wire-loop lesions suggest active Class IV Lupus Nephritis. This requires aggressive immunosuppression to prevent rapid progression to end-stage renal disease (ESRD).
Knowledge Check
What does “Diffuse” imply?
“Diffuse” indicates that more than 50% of the glomeruli are involved in the pathological process.